Toxicogenomics

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Toxicogenomics is defined as the study of the structure and function of the genome and its responds to adverse xenobiotic exposure. It is the toxicological subdiscipline of pharmacogenomics, which is broadly defined as the study of inter-individual variations in whole-genome or candidate gene single-nucleotide polymorphism maps, haplotype markers, and alterations in gene expression that might correlate with drug responses.

  • Toxicogenomics in regulatory application
  • SAR/QSAR models
  • Screening tools to predict toxicity & targets
  • Signature/biomarker qualification
  • Bioinformatics and interpretive challenges in toxicogenomics
  • Challenges of conventional toxicology approaches
  • Toxicogenomics as a predictive tool
  • Identifying critical targets or pathways
  • Gene cloning
  • Use of toxicogenomics information directly as a POD

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